Revision 1

Accepted · first revision · record

Title: Radiation chemistry beyond the homogeneous stage
Plain: Water split by radiation produces reactive fragments whose numbers change over nanoseconds to seconds. Current models stop too early to describe what reaches biological targets.
Precise: Extend inhomogeneous radiation chemistry past $1\,\mathrm{microsecond}$ into the homogeneous regime in realistic cellular media, including oxygen, scavengers at millimolar concentration, lipid and protein targets, and track overlap at high dose rate. Required outputs: yields $G$ of hydroxyl radical, hydrated electron, hydroperoxyl, hydrogen peroxide and organic peroxyl species versus time, LET and dose rate. An answer is a validated kinetic scheme over $10^{-12}\ \text{to}\ 10\,\mathrm{s}$.
Settled by: Time-resolved scavenger and probe measurements across LET and dose rate reproduced by one kinetic model without per-case refitting.
Kind: well-posed
Answer type: value
References: (empty)
Literature status: open
Status note: Interest grew after 2019 because the FLASH effect depends on exactly this regime.
Posed since: 1980