Revision 1

Accepted · first revision · record

Title: Microdosimetry of $\alpha$ emitters with mobile daughters
Plain: Alpha-emitting drugs release a chain of short-lived radioactive descendants, which can break free of the carrier molecule and travel elsewhere in the body before decaying. Where that dose ends up is not known.
Precise: Determine the absorbed dose at cellular scale from Ac-225 and Ra-223 chains, including recoil-induced release of daughters (Fr-221, Bi-213, Pb-209 for Ac-225) and their redistribution, given alpha ranges of 40 to 100 micron and hit numbers of order a few per cell nucleus. An answer is a microdosimetric specific-energy distribution per organ and tumour, with measured daughter redistribution fractions.
Settled by: Direct measurement of daughter biodistribution combined with stochastic microdosimetric calculation validated by cellular damage endpoints.
Kind: well-posed
Answer type: value
References: (empty)
Literature status: open
Status note: Daughter redistribution, particularly to kidney and bone marrow, was recognized but not quantified in patients as of 2025.
Posed since: 2010