{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"50790ed5c6b8fcf404e34f1c77ec9a51b703866df27fa558b85d0a5dfb4e63d3","created":"2026-10-15T23:43:22Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["35672b0de80e49688563501fb603e1d373fd0e8b3659b56722078b8a871523b3","ce59fb6cd812fc05906d0c60a71c75ea22bc686bcf38e7c3ef7010834d98ee7b"],"salt":"c4660038b6de546d04c22ac4ae6e26a3a2b245a9ed3a09b737e85d1e48e12765","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"identification","assisted_by":[],"external_id":"med.microdosimetry.predictive-observable","kind":"well-posed","literature_status":"open","n":"2","parents":[],"plain":"Dose alone does not predict biological damage for different particle types. The question is which microscopic measure of the energy pattern does.","posed_since":"2000","precise":"Identify a nanodosimetric quantity, such as the ionization cluster size distribution in a volume of 2 to 10 nm, lineal energy on a 1 micron site, or a DNA-weighted energy-deposition metric, that collapses measured cell-survival and chromosome-aberration data for photons, protons and ions of LET from 0.2 to 200 keV/micron onto a single curve. An answer names the quantity and shows the collapse with residuals.","problem_ref":"35672b0de80e49688563501fb603e1d373fd0e8b3659b56722078b8a871523b3","references":"","settled_by":"Joint nanodosimeter and radiobiology measurements on identical beams showing one metric that orders all endpoints consistently.","status_note":"Cluster-size based metrics outperform LET in several comparisons, but no single observable has been shown to be sufficient.","title":"Which nanoscale observable predicts biological effect?","topic_ref":null},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"2b0796129d6d16bb9e1f35f19dcfb747eb526464334e809bd67e19ad5438f13c","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"1f203176a1ebc8ad7aae5c7f708de8b8003b4901353b1fd4e24ab41b7a25fc53","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"mUXU0KfVjWSCJSa4askkprxhbMdRvePaY10aQM2PWxsiPkOpS5xug7Q5zuhoN4gb4nvpBoHlJ36CXPQNPlJZDw"},"schema":"pubphys.envelope/1"},"record_hash":"2b0796129d6d16bb9e1f35f19dcfb747eb526464334e809bd67e19ad5438f13c","leaf_index":3478}