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How to add them into one effective dose is disputed.","posed_since":"","precise":"Construct a model converting the absorbed dose components of a neutron capture field (B-10(n,$\\alpha$)Li-7 at about 2.3 MeV total kinetic energy, N-14(n,p) protons at 0.58 MeV, fast-neutron recoil protons and photons) into a photon-isoeffective dose that predicts tumour control and normal-tissue complication, replacing fixed compound and relative biological effectiveness factors. The model must include the boron microdistribution relative to the nucleus and dose-rate effects over treatment times of 30 to 60 min. An answer is a validated weighting scheme with stated uncertainty.","problem_ref":"1d83b71734906bbc3afa0057857fa7c7532f6a679ab9c83e2015f323e431b083","references":"","settled_by":"Prospective comparison of predicted and observed responses across patients or animal models with measured boron microdistribution and beam spectra.","status_note":"Fixed-factor and photon-isoeffective dose models give different prescriptions for the same treatment and both remain in use.","title":"Biological weighting of the neutron capture mixed 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