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Whether the same holds for radioactive drugs, where dose arrives slowly and unevenly, has not been shown convincingly.","posed_since":"2000","precise":"Establish whether tumour absorbed dose, computed from quantitative imaging and time-activity integration for Lu-177 labelled agents, predicts response with a slope distinguishable from zero, and whether kidney and marrow absorbed dose predicts toxicity. Typical delivered tumour doses span $10^3$ to $3 \\times 10^4\\,\\mathrm{rad}$ at dose rates of 1 to 100 rad/h. An answer is a dose-response relation with confidence intervals, or a demonstration that dose rate and biological factors dominate.","problem_ref":"eb4ebc3d8217d58dcc9db855e02324a902e876a74d5822fb4e70338b3f914b15","references":"","settled_by":"Prospective trials randomizing or stratifying by measured absorbed dose rather than administered activity.","status_note":"Dosimetry-guided dose escalation studies reported through 2024 support a relation for some agents; fixed-activity dosing remains standard practice.","title":"Does absorbed dose predict outcome in radionuclide 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