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Where and when those clouds form is only partly predictable.","posed_since":"2004","precise":"Predict the threshold and spatial extent of histotripsy bubble-cloud formation from the incident pressure waveform, with peak negative pressures of $10^8\\text{ to }3 \\times 10^8\\,\\mathrm{dyn}/\\mathrm{cm}^2$ and microsecond pulses, including nucleus distribution in tissue, shock scattering from earlier bubbles, and tissue mechanical properties. 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