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With a single sky to look at, it is hard to know if they mean anything.","posed_since":"","precise":"The anomalies are: low quadrupole power, lack of temperature correlation above 60 degrees ($S_1/2$), quadrupole-octopole alignment, hemispherical power asymmetry, the cold spot and an odd-even parity asymmetry, each at $p \\sim 0.1 \\text{ to } 1\\%$ in LCDM, with a posteriori choice of statistics. Decide whether they are flukes or physical by testing predictions fixed in advance on independent data (large-angle E-mode polarization, CMB lensing, galaxy surveys).","problem_ref":"04beebef280d10bd87ccd3d74d38f68257124bc3ecb53c4c28abee6e8f405d87","references":"","settled_by":"Pre-registered tests on large-angle polarization and lensing maps whose outcome under LCDM is predicted conditional on the temperature map.","status_note":"2025 re-analyses of foreground-cleaned low-multipole maps still find the temperature anomalies at similar significance.","title":"Are the CMB large-angle anomalies statistical flukes or 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