Diffusion MRI of tissue microstructure
Magnetic resonance scanners can track how water molecules wander inside tissue, and the wandering is slowed by cell walls and fibres far smaller than an image pixel. The open question is how much of the hidden microscopic structure can actually be read back from that signal.
Why it matters
Microstructure maps would give non-invasive measures of axon loss, tumour cellularity and tissue damage, but only if the inferred parameters are unique and correct.
Review
Novikov, Fieremans, Jespersen and Kiselev, Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation, NMR in Biomedicine, 2019. https://doi.org/10.1002/nbm.3998 reference checked
Timestamp record
- Signed record
- 7d6543da8b95…
- Public log
- Entry 269, in checkpoint 2,123
- In the log by
- Block 969,698, 2026-10-03
This text was in the PubPhys log by that date. The date says nothing about when the problem was first posed.