FLASH ultra-high dose-rate radiotherapy

Delivering a whole radiation treatment in less than a tenth of a second appears to damage healthy tissue much less than the same dose given over minutes, while killing tumours just as well. No one knows why this happens.

Why it matters

If the effect is real and controllable, the same tumour dose could be given with far less injury to the patient.

Review

Favaudon et al., Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice, Science Translational Medicine, 2014. https://doi.org/10.1126/scitranslmed.3008973 reference checked

Timestamp record

Signed record
e183d5a2701f…
Public log
Entry 271, in checkpoint 2,123
In the log by
Block 969,698, 2026-10-03

This text was in the PubPhys log by that date. The date says nothing about when the problem was first posed.

6 problems